References - Intellectual properties

Patents:

1. “Separating materials for chromatography and electrophoresis applications comprising regiodefined functionalized cyclodextrins chemically bonded to a support via urethane functionalities”
Ng Siu Choon, Zhang Li Feng, Ching Chi Bun
US Pat. No: 6,017,458, Jan 25, 2000

2. “Separating Materials for Chromatography and Electrophoresis Applications Comprising Regiodefined Functionalised
Cyclodextrins Chemically Bonded to a Support Via Urethane Functionalities
Ng Siu Choon, Ching Chi Bun, Zhang Li Feng and Chen Lei,
Singapore Pat No. 69210, 22 Aug 2000.

3. “Separating materials for chromatography and electrophoresis applications comprising regiodefined functionalized
cyclodextrins chemically bonded to a support via urethane functionalities”
Ng Siu Choon, Zhang Li Feng, Ching Chi Bun
US Pat (divisional ) No: 6,296,768, Oct 2, 2001

4. ‘Materials Comprising Saccharide Cross-Linked and Chemically Bonded to a Support via Urea Linkages Useful for
Chromatography and Electrophoresis Applications”,
Ng Siu Choon, ChingChi Bun, Zhang Li Feng and Chen Lei,
Singapore Pat, Appl. No: 20004213-5, 23 Jun 2001.

5. Materials Comprising Saccharide Cross-Linked and Chemically Bonded to a Support via Urea Linkages Useful for
Chromatography and Electrophoresis Applications
Ng Siu Choon, Ching Chi Bun, Zhang Li Feng, Chen Lei
PCT, No: WO 01/98370 A1, 22 Jun 2001

6. “Materials Comprising Saccharide Cross-Linked and Chemically Bonded to a Support via Urea Linkages Useful for
Chromatography and Electrophoresis Applications”,
Ng Siu Choon, Ching Chi Bun, Zhang Li Feng, Chen Lei
US Patent, Appl. No: 09/888,088. Filling Date: 22 Jun 2001.

7. “Materials Comprising Polymers or Oligomers of Saccharides Chemically Bonded to a Support Useful for Chromatography
and Electrophoresis Applications”,
Ng Siu Choon, Ching Chi Bun, Zhang Li Feng, Chen Lei
US Patent, Appl. No. 10/054,162, 18 Jan 2002.

Selected Papers:

1. “A facile Immobilization Approach for Perfunctionalised Cyclodextrin onto Silica via the Staudinger Reaction”,
L. F. Zhang, Y. C. Wong, L. Chen, C. B. Ching, S. C. Ng
Tetrahedron Lett., 1999, 40: (9), 1815

2. “A Facile Route into 6A-Mono-Omega-Alkenylcarbamido-6A-Deoxy-Perfunctionalised Cyclodextrin: Key Intermediate for
Further Reactive Functionalisations”,
L. F. Zhang, L. Chen, T. C. Lee, S. C. Ng,
Tetrahedron-Asymmetry, 1999, 10: (21), 4107
Chiral sciences & Technologies Pte. Ltd.

3. “Facile Preparative HPLC Enantioseparation of Racemic Drugs Using Chiral Stationary Phases Based on Mono-6A-Azido-
6A-Deoxy-Perphenylcarbamoylated ß-Cyclodextrin Immobilized on Silica Gel”,
S. C. Ng, L. Chen, L. F. Zhang, C. B. Ching
Tetrahedron Lett.,2000, 43 (4), 677

4. “Synthesis and Chromatographic Properties of A Novel Chiral Stationary Phase Derived from Heptakis(6-Azido-6-Deoxy-
2,3-Di-O-Phenylcarbamoylated)- ß-Cyclodextrin Immobilized onto Amino-Functionalized Silica Gel via Multiple Urea
Linkages”,
L. Chen, L. F. Zhang, C. B. Ching and S. C. Ng
J. Chromatogr. A, 2002, 950(1), 65

5. “Liquid Chromatographic Retention Behavior and Enantiomeric Separation of Three Chiral Center Beta-Blocker Drug
(Nadolol) Using Heptakis (6-Azido-6-Deoxy-2, 3-Di-O-Phenylcarbamolyted) Beta-Cyclodextrin Bonded Chiral Stationary
Phase”,
X Wang, C. B. Ching
Chirality, 2002, 14 (10), 798-805

6. “Optimization Of A Simulated Moving Bed Based on An Approximated Langmuir Model”
H. W. Yu, C. B. Ching
AICHE JOURNAL, 2002, 48 (10), 2240-2246

7. “Enantiomer Separation of Flavour and Fragrance Compounds By Liquid Chromatography Using Novel Urea-Covalent
Bonded Methylated Beta-Cyclodextrins on Silica”
S. C. Ng, T. T. Ong, P. Fu, C. B. Ching
J of Chromatogr A, 2002, 968 (1-2), 31-40

8. “Optimization of the Reversed-Phase High-Performance Liquid Chromatographic Separation of the Enantiomers of A
Cationic Chiral Drug (Tolperisone) on A Heptakis(6-Azido-6-Deoxy) Perphenylcarbamated Beta-Cyclodextrin Column”
T. Velmurugan, C. B. Ching, S. C. Ng, Z. W. Bai, T. T. Ong
Chromatographia, 2002, 56 (3-4), 229-232

9. “Kinetic And Equilibrium Study of the Separation of Three Chiral Center Drug, Nadolol, by HPLC on A Novel Perphenyl
Carbamoylated Beta-Cyclodextrin Bonded Chiral Stationary Phase”
X. Wang, C. B. Ching
Separation Science And Technology, 2002, 37 (11), 2567-2586

10. “Enantioseparation of Fluoxetine on A New Beta-Cyclodextrin Bonded Phase Column by HPLC”
H. W. Yu, C. B. Ching, P. Fu, S. C. Ng
Separation Science And Technology, 2002, 37 (6), 1401-1415

11. “Solubility, Metastable Zone Width, and Racemic Characterization of Propranolol Hydrochloride”
X. Wang, X. J. Wang, C. B. Ching
Chirality, 2002, 14 (4), 318-324

12. “Kinetic and Equilibrium Study of the Enantioseparation of Fluoxetine on A New Beta-Cyclodextrin Column by High
Performance Liquid Chromatography”
H. W. Yu, C. B. Ching
Chromatographia, 2001, 54 (11-12), 697-702

13. “Effect Of Mobile Phase Composition on the Separation of Propranolol Enantiomers Using A Perphenylcarbamate Beta-
Cyclodextrin Bonded Chiral Stationary Phase”
C. B. Ching, P. Fu, S. C. Ng, Y. K. Xu
J of Chromatogr A, 2000, 898 (1), 53-61